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Updated: Mar 8, 2026

Culturing and Manipulation of O9-1 Neural Crest Cells
Published on: October 9, 2018
The Hippo pathway in tissue homeostasis and regeneration
Yu Wang1, Aijuan Yu1, Fa-Xing Yu2,3,4
1Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Abstract:
While several organs in mammals retain partial regenerative capability following tissue damage, the underlying mechanisms remain unclear. Recently, the Hippo signaling pathway, better known for its function in organ size control, has been shown to play a pivotal role in regulating tissue homeostasis and regeneration. Upon tissue injury, the activity of YAP, the major effector of the Hippo pathway, is transiently induced, which in turn promotes expansion of tissue-resident progenitors and facilitates tissue regeneration. In this review, with a general focus on the Hippo pathway, we will discuss its major components, functions in stem cell biology, involvement in tissue regeneration in different organs, and potential strategies for developing Hippo pathway-targeted regenerative medicines.
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