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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
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Bone-Fat Interaction.

Elizabeth Rendina-Ruedy1, Clifford J Rosen1

  • 1Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA.

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|January 30, 2017
PubMed
Summary
This summary is machine-generated.

Marrow adipose tissue (MAT), an endocrine organ, influences bone health and metabolic homeostasis. Research indicates MAT is inversely associated with bone density and quality, highlighting its role in bone turnover.

Keywords:
AdiposityBone marrowMarrow adipose tissueMarrow fat

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Metabolic Homeostasis

Background:

  • Marrow adipose tissue (MAT) is a recently identified endocrine organ.
  • Its proximity to the bone microenvironment makes its impact on bone significant.
  • Alterations in MAT are observed in various disease states, offering functional insights.

Purpose of the Study:

  • To explore the role of marrow adipocytes in bone health.
  • To understand the relationship between MAT and bone density/quality.
  • To investigate MAT's contribution to metabolic homeostasis.

Main Methods:

  • Review of existing scientific literature on marrow adipose tissue.
  • Analysis of conditions and disease states associated with MAT alterations.
  • Synthesis of data on the relationship between MAT and bone parameters.

Main Results:

  • MAT is recognized as an active, dynamic endocrine depot.
  • A consensus exists that MAT is inversely associated with bone density and quality.
  • MAT plays a role in bone turnover and overall metabolic homeostasis.

Conclusions:

  • Marrow adipose tissue significantly impacts bone microenvironment and health.
  • MAT's inverse relationship with bone density and quality is a key finding.
  • Further research is warranted to fully elucidate MAT's functions in bone turnover and metabolic regulation.