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Updated: Mar 8, 2026

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
Neonatal pain management
Brian S Carter1, Jessica Brunkhorst2
1Department of Pediatrics, Division of Neonatology, University of Missouri at Kansas City School of Medicine, 2401 Gillham Rd, Kansas City, MO 64108; Children׳s Mercy Bioethics Center, Kansas City, MO.
Insights
Effective pain management in the neonatal intensive care unit (NICU) requires understanding pain scales, non-pharmacologic methods, and various medications. This review covers general principles, procedural pain, end-of-life care, chronic pain, and neonatal abstinence.
Area of Science:
- Neonatal intensive care
- Pain management
- Clinical practice
Background:
- Pain management in neonatal intensive care units (NICUs) presents significant challenges for clinicians.
- Complex care situations further complicate effective pain control strategies.
Purpose of the Study:
- To review general principles of pain management applicable to neonatal intensive care.
- To discuss the utility of pain scales, non-pharmacologic interventions, and pharmacologic agents.
- To address specific contexts including procedural pain, end-of-life care, chronic pain, and neonatal abstinence syndrome.
Main Methods:
- Literature review of general pain management principles.
- Synthesis of information on pain assessment tools (pain scales).
- Overview of non-pharmacologic and pharmacologic pain management strategies.
Main Results:
- Pain scales are crucial for assessing and monitoring pain in neonates.
- Non-pharmacologic interventions offer a foundational approach to pain relief.
- Various pharmacologic agents can be utilized for procedural pain, ongoing pain, and end-of-life care.
Conclusions:
- Comprehensive pain management in the NICU involves a multimodal approach.
- Addressing chronic pain and neonatal abstinence is essential for long-term infant well-being.
- Clinicians need a thorough understanding of available pain management options.
Abstract:
Pain management in the neonatal ICU remains challenging for many clinicians and in many complex care circumstances. The authors review general pain management principles and address the use of pain scales, non-pharmacologic management, and various agents that may be useful in general neonatal practice, procedurally, or at the end of life. Chronic pain and neonatal abstinence are also noted.
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