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Related Concept Videos

Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
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Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
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Cutis Laxa.

Jayakar Thomas, P Krishnamurthy, T C Muthuswami

    Indian Journal of Dermatology, Venereology and Leprology
    |January 31, 2017
    PubMed
    Summary
    This summary is machine-generated.

    This case study describes a 20-year-old male with cutis laxa, a rare genetic disorder causing loose, sagging skin. The condition resulted in a prematurely aged appearance on his face and neck.

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    Area of Science:

    • Dermatology
    • Medical Genetics

    Background:

    • Cutis laxa is a rare connective tissue disorder characterized by generalized, loose, sagging skin.
    • It can be inherited or acquired, affecting both males and females.

    Observation:

    • A 20-year-old male presented with significant loose, pendulous skin on his face and neck.
    • The skin laxity gave him a prematurely aged appearance.

    Findings:

    • The patient exhibited classic clinical manifestations of cutis laxa.
    • Diagnosis was based on the characteristic phenotype of extreme skin elasticity and laxity.

    Implications:

    • This case highlights the phenotypic variability and early onset potential of cutis laxa.
    • Early diagnosis and management are crucial for improving patient quality of life and addressing potential systemic complications.