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Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Metastasis02:30

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Mar 8, 2026

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
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Going live with tumor exosomes and microvesicles.

Vincent Hyenne1,2,3,4,5, Olivier Lefebvre1,2,3,4, Jacky G Goetz1,2,3,4

  • 1a Inserm U1109, MN3T , Strasbourg , France.

Cell Adhesion & Migration
|February 1, 2017
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Tumor extracellular vesicles (EVs) drive cancer progression and metastasis by communicating with the tumor microenvironment. New in vivo imaging reveals their role in preparing pre-metastatic niches.

Keywords:
exosomeextracellular vesicleimagingmicrovesiclepre-metastatic niche

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Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Tumor extracellular vesicles (EVs), including exosomes, mediate communication within the tumor microenvironment.
  • In vitro and in vivo studies demonstrate EVs' capacity to alter stromal and tumor cell phenotypes.

Purpose of the Study:

  • To review functional approaches and in vivo imaging progress for understanding tumor EVs.
  • To highlight the role of tumor EVs in priming pre-metastatic niches (PMN).

Main Methods:

  • Review of functional studies on tumor EVs.
  • Analysis of recent advances in in vivo EV imaging techniques.
  • Examination of molecular cargo (RNAs, proteins) within tumor EVs.

Main Results:

  • Tumor EVs are key mediators of pro-tumorigenic communication.
  • Tumor EVs play a critical role in priming pre-metastatic niches.
  • Specific EV-transported molecules are essential for tumor progression and metastasis.

Conclusions:

  • In vivo imaging has significantly advanced the understanding of tumor EV function.
  • Further research is needed to address remaining challenges in tumor EV biology.