Related Experiment Video
Updated: Mar 8, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
[Argentine guidelines for the diagnosis, prevention and treatment of osteoporosis, 2015]
León Schurman1, Ana M Galich2, Claudio González3
1Laboratorio de Investigación en Osteopatías y Metabolismo Mineral (LIOMM), Universidad Nacional de La Plata, Buenos Aires, Argentina.
Abstract:
Osteoporosis is an evolving disease which affects over 200 million people worldwide. Our recommendations are guidelines for its diagnosis, prevention and treatment, but they do not constitute standards for clinical decisions in individual cases. The physician must adapt them to individual special situations, incorporating personal factors that transcend the limits of these guidelines and are dependent on the knowledge and art of the practice of Medicine. These guidelines should be reviewed and updated periodically as new, better and more effective diagnostic and therapeutic tools become available.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Angina IV: Management
Bone Remodeling
Urinary Tract Calculi IV: Nutrition Therapy and Prevention