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Related Experiment Video

Updated: Mar 8, 2026

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

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Published on: April 13, 2018

Renal Aging: Causes and Consequences.

Eoin D O'Sullivan¹, Jeremy Hughes^2,3, David A Ferenbach^2,3,4,5

¹Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; eoindosullivan@gmail.com.

Journal of the American Society of Nephrology : JASN

|February 2, 2017

Summary

This summary is machine-generated.

The aging kidney shows structural and functional changes, increasing susceptibility to acute kidney injury (AKI) and chronic kidney disease (CKD). Understanding these age-associated kidney alterations is crucial for developing new treatments.

Keywords:

Aging glomerulosclerosis kidney dysfunction metabolism molecular biology progression of renal failure

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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

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Published on: November 26, 2017

Area of Science:

Nephrology
Gerontology
Renal Physiology

Background:

The population aged over 65 is rapidly expanding globally.
Older individuals increasingly receive diagnoses of impaired renal function and nephrosclerosis.
The aged kidney exhibits structural, transcriptomic, hemodynamic, and physiological alterations.

Purpose of the Study:

To review the structural and functional changes in the aged kidney.
To explore pathways contributing to age-associated kidney changes in humans and animal models.
To identify potential therapeutic strategies for the aging kidney.

Main Methods:

Review of recent studies on aged kidney physiology and pathology.
Examination of experimental animal models and human data.
Analysis of transcriptomic, hemodynamic, and physiological data.

Main Results:

Aging impairs the kidney's ability to withstand and recover from injury.
Age-associated kidney changes increase susceptibility to acute kidney injury (AKI).
These changes contribute to a higher propensity for developing progressive chronic kidney disease (CKD).

Conclusions:

The aged kidney has unique characteristics that predispose it to injury and disease.
Further research is needed to fully understand these changes and develop targeted therapies.
Novel therapeutic strategies may emerge from a deeper understanding of aging kidney biology.