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Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by

Anchal Sharma1, Asgar Hussain Ansari1, Renu Kumari1

  • 1Genomics & Molceular Medicine Unit, CSIR-Institute of Genomics & Integrative Biology, Delhi, 110020, India; Academy of Scientific and Innovative Research, CSIR-Institute of Genomics & Integrative Biology (AcSIR-IGIB), Delhi, 110020, India.

F1000Research
|February 7, 2017
PubMed
Summary

The normal human brain contains somatic DNA variations, with a high rate of G:C>T:A transversions linked to oxidative stress markers in the frontal cortex. These variations may affect axon guidance pathways.

Keywords:
8-OHdGG:C>T:A transversions.SNVsaxon guidancebrainexome sequencingoxidative stresssomatic variations

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