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Hepatitis C virus and cardiovascular: A review

Salvatore Petta1

  • 1Sezione di Gastroenterologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Piazza delle Cliniche, 2, 90127 Palermo, Italy.

Journal of Advanced Research
|February 3, 2017
PubMed

Insights

Chronic hepatitis C virus (HCV) infection may increase cardiovascular risk. Further research is needed to confirm this link and the benefits of HCV treatment on heart health.

Area of Science:

  • Hepatology
  • Cardiology
  • Virology

Background:

  • Chronic hepatitis C virus (HCV) infection is a systemic illness linked to cirrhosis, extrahepatic disorders, and metabolic issues like insulin resistance.
  • Emerging evidence suggests a connection between HCV infection and increased cardiovascular risk, with potential benefits from viral eradication.
  • However, conflicting data and the high prevalence of both conditions create uncertainty regarding a direct association.

Purpose of the Study:

  • To review existing data on the relationship between HCV infection and cardiovascular risk.
  • To explore potential mechanisms linking HCV to vascular damage.
  • To assess the impact of HCV viral eradication on cardiovascular outcomes.

Main Methods:

  • Systematic review of current literature.
  • Analysis of studies investigating HCV infection and cardiovascular alterations.
  • Evaluation of evidence on mechanisms and outcomes of HCV treatment.

Main Results:

  • Accumulating evidence suggests HCV infection may elevate cardiovascular risk.
  • Potential mechanisms linking HCV to vascular damage have been identified.
  • Conflicting results exist, necessitating further investigation.

Conclusions:

  • The precise role of HCV in cardiovascular alterations requires definitive clarification.
  • The impact of viral eradication on cardiovascular outcomes needs further study.
  • New, effective antiviral therapies make this research timely.

Keywords:
AtherosclerosisCardiovascular riskDeathFibrosisHCVHearth

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