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Related Experiment Video

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Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats
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3D myocardial T1 mapping using saturation recovery.

Giovanna Nordio1, Markus Henningsson1, Amedeo Chiribiri1

  • 1Division of Imaging Science and Biomedical Engineering, King's College London, London, UK.

Journal of Magnetic Resonance Imaging : JMRI
|February 3, 2017
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Summary

A new 3D SASHA technique enables high-resolution, free-breathing T1 mapping of the entire heart. This advanced method shows good agreement with existing protocols and improved precision for cardiac imaging.

Keywords:
MRIT1 mappingaccuracyprecisionsaturation-recovery

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Area of Science:

  • Cardiovascular Magnetic Resonance Imaging
  • Quantitative Imaging Techniques

Background:

  • Accurate T1 mapping is crucial for assessing myocardial tissue characteristics.
  • Current techniques often require breath-holding, limiting whole-heart coverage and patient comfort.

Purpose of the Study:

  • To introduce and validate a novel 3D quantitative high-resolution T1 mapping technique, 3D SASHA (saturation-recovery single-shot acquisition).
  • To enable free-breathing whole-heart T1 mapping using respiratory motion compensation.

Main Methods:

  • Implementation of 3D SASHA on a 1.5T scanner with a diaphragmatic navigator for respiratory motion compensation.
  • Acquisition of images with a resolution of 1.4 × 1.4 × 8 mm³.
  • Validation in a T1 phantom against IRSE and in 10 healthy volunteers against 2D MOLLI and 2D SASHA.

Main Results:

  • Excellent agreement between 3D SASHA and reference IRSE in phantom T1 measurements (1111.6 ± 31 msec vs. 1123.6 ± 8 msec, P=0.9947).
  • Myocardial T1 values in healthy subjects: 881 ± 40 msec (2D MOLLI), 1181.3 ± 32 msec (2D SASHA), and 1153.6 ± 28 msec (3D SASHA).

Conclusions:

  • The 3D SASHA sequence provides high-resolution, free-breathing whole-heart T1 mapping.
  • Achieved T1 values demonstrate good agreement with 2D SASHA and exhibit improved precision.