[Dynamics of Campylobacter jejuni invasion in gnotobiotic piglets]

The study deals with the results of the investigation of C. jejuni populations in the intestines of gnotobiotic piglets after oral infection with C. jejuni in the span of one to five days after infection (DAI). The infection of the whole large intestine was revealed, with the onset of pathological lesions 3rd DAI. C. jejuni was isolated from liver, gallbladder, ileum, rectum, colon, mesenterial lymphatic node, rectal smears and blood. From 1st to 5th DAI C. jejuni was demonstrated in liver, gallbladder and posterior part of ileum. In the cecum and rectum C. jejuni was detected as late as on 2nd-3rd DAI to 5th DAI and in mesenterial lymphatic nodes from 2nd to 4th DAI. In rectal smears C. jejuni was found out regularly during the whole period of experiment. C. jejuni was also isolated from inflammatory infiltrate. Histological examination revealed C. jejuni between the villi and in the contents of cup-shaped cells from 2nd to 5th DAI.