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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
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Sleep in the Aging Population.

Brienne Miner1, Meir H Kryger2

  • 1Department of Internal Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

Sleep Medicine Clinics
|February 5, 2017
PubMed
Summary
This summary is machine-generated.

Sleep needs don't decrease with age, and sleep disturbance isn't normal aging. Sleep problems in older adults stem from multiple health and lifestyle factors, requiring comprehensive geriatric care.

Keywords:
AgingGeriatric syndromesInsomniaMultimorbidityPolypharmacySleep disorders

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Area of Science:

  • Geriatric Medicine
  • Sleep Science
  • Public Health

Background:

  • Sleep architecture undergoes normal changes across the lifespan.
  • Sleep disturbance is not an inherent aspect of aging.
  • Older adults frequently experience sleep disturbances due to various factors.

Purpose of the Study:

  • To examine the prevalence and contributing factors of sleep disturbance in older adults.
  • To emphasize that sleep disturbance is not a normal part of aging.
  • To advocate for a multifactorial approach to managing sleep issues in geriatrics.

Main Methods:

  • Review of existing literature on sleep changes, aging, and associated health conditions.
  • Analysis of factors contributing to sleep disturbance in the geriatric population.
  • Synthesis of evidence supporting a geriatric health condition model for sleep complaints.

Main Results:

  • Aging is linked to increased multimorbidity, polypharmacy, psychosocial issues, and primary sleep disorders, all impacting sleep.
  • Sleep disturbance in older adults is common but not an inevitable consequence of aging.
  • These sleep disturbances are associated with significant morbidity and mortality.

Conclusions:

  • Sleep complaints in older adults are best understood as a multifactorial geriatric health condition.
  • A multifaceted treatment approach is necessary to address the complex factors affecting sleep in this population.
  • Interventions should consider the interplay of medical, pharmaceutical, psychosocial, and sleep-specific factors.