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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Esophageal Varices-I: Introduction01:24

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Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
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Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
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Related Experiment Video

Updated: Mar 7, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
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Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

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Cutaneous Metastasis In- Oesophagealcarcinoma.

S Tharakaram, T V Kumar

    Indian Journal of Dermatology, Venereology and Leprology
    |February 7, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Esophageal carcinoma can spread to the skin, causing firm nodules. This case highlights cutaneous metastases as a rare presentation of esophageal cancer.

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    Area of Science:

    • Oncology
    • Dermatology
    • Gastroenterology

    Background:

    • Esophageal carcinoma is a malignancy of the esophagus.
    • Cutaneous metastases are secondary cancerous growths in the skin.

    Observation:

    • A 67-year-old male patient presented with multiple firm to hard cutaneous nodules across his body.
    • The patient had a known diagnosis of esophageal carcinoma.

    Findings:

    • Biopsy confirmed the skin nodules to be metastatic deposits from the primary esophageal tumor.
    • This indicates a rare instance of esophageal carcinoma metastasizing to the skin.

    Implications:

    • This case underscores the importance of considering cutaneous metastases in patients with advanced esophageal cancer.
    • Skin metastasis can be an indicator of widespread disease and may influence treatment strategies.