Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of physiological strain on lung epithelial cells by exposure to aerosolised quartz silica in a perfused bioreactor.

Frontiers in bioengineering and biotechnology·2026

Same author

Passage-Dependent Size Distributions of Human-Derived Cells: Implications for Metabolic Assays.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

Same author

What's in a NAM?

Lab animal·2026

Same author

Evolvoid: a genetic algorithm for shaping optimal cellular constructs.

Journal of biological engineering·2026

Same author

Mild Ozone-Induced Oxidative Stress Modulates the Activity and Viability of Porcine Neutrophils and Monocytes.

Animals : an open access journal from MDPI·2026

Same author

Engineering a smart intrauterine device based on pH-controlled copper release.

Bioengineering & translational medicine·2025

Same journal

Peripheral B-cell receptor repertoire predicts immune-related adverse events following immune checkpoint inhibitor therapy in advanced renal cell carcinoma.

Scientific reports·2026

Same journal

Effects of black soldier fly (Hermetia illucens L.) larvae zoocompost on the mineral element content of blue honeysuckle berries.

Scientific reports·2026

Same journal

Investigation on absorption refrigeration performance of R1243zf with imidazolium ionic liquid as the working pairs.

Scientific reports·2026

Same journal

DeepTriage-CN: integrating clinical text with vital signs for emergency department admission prediction in an aging population.

Scientific reports·2026

Same journal

Gold nanoparticles as dual-action antiviral agents: disruption of SARS-CoV-2 viral envelopes and RNA integrity.

Scientific reports·2026

Same journal

Comparison of capillary microsampling and venous blood for multi-pathogen serosurveillance.

Scientific reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 7, 2026

Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila

Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila

Published on: October 1, 2011

Allometric scaling in-vitro.

Arti Ahluwalia¹

¹Department of Information Engineering and Research Center E.Piaggio, University of Pisa, Pisa, Italy.

Scientific Reports

|February 8, 2017

Summary

This summary is machine-generated.

This study presents a framework for achieving quarter power scaling in in-vitro tissue cultures. This could enable more predictive and physiologically relevant cell-based research models.

More Related Videos

Author Spotlight: Advancing Bone Cell Activity Research with Zebrafish Scales

Author Spotlight: Advancing Bone Cell Activity Research with Zebrafish Scales

Published on: January 10, 2025

Author Spotlight: Use of Fish Scales for Bone Remodeling Research – Advancements in Ex Vivo Imaging and Dissecting Cell Interactions

Author Spotlight: Use of Fish Scales for Bone Remodeling Research – Advancements in Ex Vivo Imaging and Dissecting Cell Interactions

Published on: May 3, 2024

Related Experiment Videos

Last Updated: Mar 7, 2026

Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila

Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila

Published on: October 1, 2011

Author Spotlight: Advancing Bone Cell Activity Research with Zebrafish Scales

Author Spotlight: Advancing Bone Cell Activity Research with Zebrafish Scales

Published on: January 10, 2025

Author Spotlight: Use of Fish Scales for Bone Remodeling Research – Advancements in Ex Vivo Imaging and Dissecting Cell Interactions

Author Spotlight: Use of Fish Scales for Bone Remodeling Research – Advancements in Ex Vivo Imaging and Dissecting Cell Interactions

Published on: May 3, 2024

Area of Science:

Physiology
Biophysics
Cell Biology

Background:

Metabolic rate in organisms scales with mass via a three-quarter power law, attributed to fractal nutrient distribution.
In-vitro cultures obeying allometric metabolic scaling could enhance research predictability and reduce animal use.

Purpose of the Study:

To develop a theoretical and computational framework for quarter power scaling in 3D spherical in-vitro constructs.
To determine conditions for maintaining physiological scaling in non-vascular tissue models.

Main Methods:

Utilized models of Michaelis Menten oxygen consumption and diffusion.
Assessed allometric scaling in non-vascular spherical tissue constructs.
Developed a computational framework for in-vitro quarter power scaling.

Main Results:

Physiological scaling is maintained when 5-60% of the construct experiences oxygen below the Michaelis Menten constant.
A significant oxygen concentration gradient exists within the spherical constructs.
The framework successfully models quarter power scaling in 3D spherical constructs.

Conclusions:

Established a framework for quarter power scaling in 3D in-vitro spherical constructs.
Demonstrated conditions for maintaining physiological relevance in engineered tissues.
Findings have implications for designing predictive, downscaled in-vitro research systems.