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Updated: Mar 7, 2026
08:42
Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
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Bile acid disease: the emerging epidemic
Ibironke Oduyebo1, Michael Camilleri
1Division of Gastroenterology and Hepatology, Mayo Clinic, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Rochester, Minnesota, USA.
Current Opinion in Gastroenterology
|February 8, 2017
Summary
Recent advances in bile acids highlight their role in chronic diarrhea and other conditions. New diagnostic tests and therapeutic targets, like the FGF-19 pathway, are improving patient outcomes.
Area of Science:
- Gastroenterology
- Endocrinology
- Metabolic Diseases
Background:
- Bile acids are crucial signaling molecules involved in digestion and metabolism.
- Bile acid diarrhea (BAD) is a significant cause of chronic diarrhea, affecting up to 30% of patients.
- Advances in understanding bile acid regulation have improved diagnosis and treatment of related disorders.
Purpose of the Study:
- To review recent advancements in bile acid research within the last two years.
- To highlight the role of bile acids in both health and disease states.
- To discuss novel diagnostic and therapeutic strategies for bile acid-related conditions.
Main Methods:
- Systematic review of literature published in the last two years.
- Analysis of studies focusing on bile acid synthesis, regulation, and signaling.
- Evaluation of diagnostic tests and therapeutic interventions for bile acid-related disorders.
Main Results:
- Bile acid diarrhea (BAD) mechanisms involve fibroblast growth factor 19 (FGF-19) regulation and the TGR5 receptor.
- SeHCAT scanning and serum FGF-19/C4 measurements are key diagnostic tools for BAD.
- Bile acid sequestrants and targeting the FXR-FGF-19 pathway offer therapeutic options for BAD.
- Bile acids mediate beneficial effects of bariatric surgery on obesity, glycemic control, and C. difficile infection.
Conclusions:
- Renewed interest in bile acids is driving innovative management strategies for various diseases.
- Understanding bile acid signaling pathways opens new avenues for therapeutic development.
- Bile acids play a multifaceted role beyond digestion, impacting metabolic and infectious diseases.
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