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Targeting Transforming Growth Factor-β Signaling in Primary Open-Angle Glaucoma
Jenny Wang1, Alon Harris, Mark A Prendes
1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN.
Journal of Glaucoma
|February 8, 2017
Summary
Transforming growth factor-β (TGF-β) is implicated in primary open-angle glaucoma (POAG) pathogenesis by increasing resistance in the trabecular meshwork. Targeting TGF-β offers novel therapeutic strategies for POAG beyond lowering intraocular pressure.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Molecular Biology
Background:
- Elevated transforming growth factor-β (TGF-β) levels are observed in glaucoma patients' aqueous humor and optic nerve astrocytes.
- Primary open-angle glaucoma (POAG) involves trabecular meshwork (TM) outflow resistance, leading to elevated intraocular pressure and retinal ganglion cell death.
Purpose of the Study:
- To review the role of TGF-β in POAG pathophysiology.
- To explore potential therapeutic strategies targeting TGF-β for POAG treatment.
Main Methods:
- Discussion of current understanding of TGF-β's role in POAG.
- Examination of TGF-β targeting at production, activation, signaling, and regulation levels.
Main Results:
- TGF-β is hypothesized to increase TM outflow resistance by altering extracellular matrix homeostasis and cell contractility.
- TGF-β may also contribute to optic nerve head damage in POAG.
Conclusions:
- Current POAG therapies focus on lowering intraocular pressure, neglecting TM extracellular matrix homeostasis.
- Targeting TGF-β represents a promising therapeutic avenue for POAG, addressing underlying pathophysiology.
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