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Endolymphatic Sac Tumor in Two Dogs.
K J Barnes1, V Clear2, K Youmans3
11 Diagnostic Center for Population and Animal Health, Michigan State University, Lansing, MI, USA.
Veterinary Pathology
|February 8, 2017
Summary
Two dogs developed rare middle ear tumors (endolymphatic sac tumors) with aggressive bone invasion, mirroring human cases. This finding aids in diagnosing and understanding these aggressive neoplasms in veterinary medicine.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
Background:
- Endolymphatic sac tumors (ELSTs) are rare human neoplasms of the inner ear.
- Diagnosis is challenging, relying on histology, immunohistochemistry, and clinical data.
- Human ELSTs are clinically aggressive, invading temporal bone despite lacking malignant cellular features.
Observation:
- Two dogs presented with middle ear masses.
- Advanced imaging revealed aggressive behavior, including temporal bone lysis.
- Histopathology showed papillary epithelial structures with mild cellular atypia and no mitotic figures.
Findings:
- Canine middle ear masses exhibited similarities to human ELSTs in morphology and immunohistochemistry.
- Neoplastic cells were positive for cytokeratin AE1/AE3 and negative for neuroendocrine markers.
- Tumors demonstrated local invasion and bone destruction without metastasis.
Implications:
- This study identifies a potential canine model for human endolymphatic sac tumors.
- Findings enhance diagnostic capabilities for canine middle ear neoplasms.
- Understanding the aggressive behavior in dogs may offer insights into human ELST pathogenesis.
