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Molecular Weight of Step-Growth Polymers

Molecular Weight of Step-Growth Polymers

Step growth polymerization involves bi or multifunctional monomers. Bifunctional monomers react to form linear step growth polymers, whereas multifunctional monomers react to form non-linear or branched polymers.
As the step-growth polymerization involves step-wise condensation of monomers, the molecular weight also builds up eventually. Consequently, high molecular weight polymers are obtained at the late stages of the polymerization, where 99% of monomers have been consumed.
The extent of the...

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Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

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Particulate Release From Nanoparticle-Loaded Shape Memory Polymer Foams.

Adam L Nathan¹, Grace K Fletcher¹, Mary Beth B Monroe¹

¹Biomedical Engineering, Texas A&M University, College Station, TX 77843.

Journal of Medical Devices

|February 10, 2017

Summary

This summary is machine-generated.

Shape memory polymer (SMP) foams for vascular occlusion devices show low particulate generation. These biocompatible foams meet safety standards, posing no significant risk for medical applications.

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Area of Science:

Biomaterials Science
Polymer Chemistry
Medical Device Development

Background:

Shape memory polymer (SMP) foams are being developed for vascular occlusion devices.
High surface area materials in the vasculature raise concerns about particulate burden.

Purpose of the Study:

To assess particulate generation from SMP foams for vascular occlusion devices.
To evaluate the biocompatibility of SMP foam particulates.

Main Methods:

Quantified particulate numbers and sizes in SMP foams (as-made, post-reticulation, nanoparticle-enhanced).
Assessed fibroblast cell viability after exposure to concentrated particulate treatments.

Main Results:

SMP foam particulate numbers and sizes comply with relevant standards and guidance.
Fibroblast cell viability remained high (100%) after particulate exposure.

Conclusions:

SMP foams demonstrate acceptable particulate generation for vascular occlusion devices.
The risk associated with particulate generation from SMP foams is not unacceptable.