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Updated: Mar 7, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
Published on: June 10, 2025
[Examination procedure and description of skin lesions]
Falk Ochsendorf1, Laura Meister2
1Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland. ochsendorf@em.uni-frankfurt.de.
Abstract:
The dermatologic examination follows a clear structure. After a short history is taken, the whole skin is inspected. The description, which is ideally provided in writing, forces one to look at the skin more closely. The description should include an accurate description of the location, the distribution, the form, and the type of lesion. The article contains tables with internationally approved definitions to describe skin changes. The analysis of these findings allows one to deduce pathophysiologic mechanisms occurring in the skin and to deduce hypotheses, i. e., suspected and differential diagnoses. These are confirmed or excluded by further diagnostic measures. The expert comes to a diagnosis very quickly by a pattern-recognition process, whereby novices must still develop this kind of thinking. Experts can minimize cognitive bias by reflective analytical reasoning and reorganization of knowledge.
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