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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Multipotent Stem Cell and Current Application.

Aligholi Sobhani1, Neda Khanlarkhani1, Maryam Baazm2

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Multipotent stem cells are versatile cells crucial for development and repair. These cells show promise in treating various conditions, including injuries and autoimmune diseases.

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Area of Science:

  • Cell Biology
  • Regenerative Medicine

Background:

  • Stem cells are undifferentiated cells with self-renewal and differentiation capabilities.
  • Stem cells are broadly categorized into embryonic and adult types.
  • Differentiation potential classifies stem cells as totipotent, pluripotent, multipotent, or unipotent.

Purpose of the Study:

  • To highlight the significance of multipotent stem cells.
  • To discuss the applications and advantages of multipotent stem cells.

Main Methods:

  • Literature review on stem cell classification and properties.
  • Analysis of multipotent stem cell roles in biological processes.
  • Compilation of therapeutic applications of multipotent stem cells.

Main Results:

  • Multipotent stem cells differentiate within a specific lineage.
  • These cells are vital for development, tissue repair, and protection.
  • Significant therapeutic potential demonstrated in various disorders.

Conclusions:

  • Multipotent stem cells offer substantial advantages for regenerative medicine.
  • Their application in treating spinal cord injury, bone fractures, and autoimmune diseases is promising.
  • Further research into multipotent stem cells can advance treatments for hematopoietic defects and fertility preservation.