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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Gut microbiota and gastric disease
Dolores Sgambato1, Agnese Miranda2, Lorenzo Romano2
1Hepatogastroenterology Unit, L. Vanvitelli University of Campania, Naples, Italy - dolores.sgambato@gmail.com.
Minerva Gastroenterologica E Dietologica
|February 17, 2017
Summary
The stomach
Area of Science:
- Microbiology
- Gastroenterology
- Human Physiology
Background:
- The gut microbiota is vital for health and disease balance.
- The stomach was historically considered sterile due to high acidity.
- Helicobacter pylori (HP) discovery revealed stomach's microbial inhabitants.
Purpose of the Study:
- To explain the cross-talk between gastric microbiota and homeostasis.
- To review the relationship between HP and non-HP bacteria.
- To examine the impact of diet and proton pump inhibitors (PPIs) on gastric microbiota.
Main Methods:
- Literature review focusing on gastric microbiota composition.
- Analysis of the interplay between gastric mucosa and microflora.
- Examination of the role of gastric microbiota in digestive disorders.
Main Results:
- Gastric microbiota comprises HP and non-HP bacteria.
- Microbial interactions influence gastric homeostasis.
- Gastric microbiota is implicated in functional dyspepsia, premalignant lesions, and gastric cancer.
Conclusions:
- The stomach harbors a complex microbiota influencing health.
- Understanding gastric microbiota is key to managing digestive diseases.
- Exogenous factors like diet and PPIs significantly affect gastric microbial communities.
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