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Updated: Aug 9, 2026

Murine Model of CD40-activation of B cells
Published on: March 6, 2010
Murine and human T11 (CD2) cDNA sequences suggest a common signal transduction mechanism
L K Clayton1, P H Sayre, J Novotny
1Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115.
Abstract:
The murine equivalent of the cDNA encoding the human T11 (CD2) sheep erythrocyte-binding protein has been cloned. It codes for a putative transmembrane protein which is homologous to human T11. In contrast to immunoglobulins whose domains consist of anti-parallel beta sheets, we predict that mouse and human T11 external domains probably belong to the alpha/beta protein folding class. The cytoplasmic region of T11 is a lengthy, proline-rich segment; secondary structural analysis predicts it to have a nonglobular conformation. This elongated tail could allow for interaction with multiple other intracellular proteins and may contain a cation-binding site involved in T lineage activation.
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