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Metabolic pathways regulated by p63.

Eleonora Candi1, Artem Smirnov2, Emanuele Panatta2

  • 1Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy; IDI-IRCCS "Istituto Dermopatico dell'Immacolata", Biochemistry Laboratory, Rome, Italy.

Biochemical and Biophysical Research Communications
|February 19, 2017
PubMed
Summary
This summary is machine-generated.

The transcription factor p63, a p53-family member, regulates epithelial cell functions. Its isoforms, TAp63 and ΔNp63, play distinct roles in cancer, influencing cell metabolism and metabolic reprogramming.

Keywords:
GlycolysisMetabolismp53 familyp63

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Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Cell Metabolism

Background:

  • p63 is a key transcription factor in the p53 family, crucial for epithelial development and homeostasis.
  • p63 exhibits isoform-specific roles in cancer, with TAp63 acting as a tumor suppressor and ΔNp63 as an oncogene.
  • p53 and TAp73 are known regulators of cancer cell metabolism, suggesting a similar role for p63.

Purpose of the Study:

  • To review the role of p63 isoforms (TAp63 and ΔNp63) in regulating cellular metabolism.
  • To highlight the specific metabolic target genes influenced by each p63 isoform.
  • To discuss the physiological and functional context of p63's metabolic control in cancer.

Main Methods:

  • Literature review of studies on p63, cancer metabolism, and metabolic reprogramming.
  • Analysis of isoform-specific functions of TAp63 and ΔNp63.
  • Examination of reported p63 target genes involved in metabolic pathways.

Main Results:

  • TAp63 and ΔNp63 differentially regulate key metabolic pathways.
  • Specific metabolic genes are identified as targets for each p63 isoform.
  • These regulatory roles have significant implications for metabolic reprogramming in cancer cells.

Conclusions:

  • p63 isoforms play a critical, yet underappreciated, role in controlling cancer cell metabolism.
  • Understanding these isoform-specific metabolic functions is essential for developing targeted cancer therapies.
  • Further research into p63's metabolic targets will illuminate its broader impact on tumor progression.