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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Two Furanharzianones with 4/7/5/6/5 Ring System from Microbial Transformation of Harzianone
Min Zhang1, Jimei Liu1, Ridao Chen1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, ‡Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, and §Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 100050, P. R. China.
Abstract:
Furanharzianones A and B (2 and 3), two new harziane-type diterpenoids with a tetrahydrofuran and unusual 4/7/5/6/5 ring system, were obtained from the microbial transformation of harzianone (1) by a bacterial strain Bacillus sp. IMM-006. The structures, including the stereochemistry, of the two new compounds were elucidated by extensive spectroscopic analysis. The absolute configuration of 2 was unambiguously determined by single-crystal X-ray diffraction. In addition, a plausible bioconversion pathway was proposed.
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