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Development of an Electrochemical DNA Biosensor to Detect a Foodborne Pathogen
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DNA Generated Electric Current Biosensor.

Lanshuang Hu1, Shengqiang Hu1, Linyan Guo1

  • 1College of Chemistry and Chemical Engineering, Central South University , Changsha, China , 410083.

Analytical Chemistry
|February 22, 2017
PubMed
Summary
This summary is machine-generated.

Deoxyribonucleic acid (DNA) can now generate electricity for molecular electronics. This new DNA-based redox current enables electrochemical detection of the breast cancer biomarker HER2, simplifying biosensor technology.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nanotechnology

Background:

  • Deoxyribonucleic acid (DNA) primarily functions as genetic material.
  • DNA holds potential as a biologic energy source for molecular electronics.
  • Developing novel biosensors for early disease detection is crucial.

Purpose of the Study:

  • To demonstrate that DNA can generate a redox electric current.
  • To utilize DNA-generated redox current for electrochemical detection of HER2, a breast cancer biomarker.
  • To establish a simplified signal transduction method for aptasensors.

Main Methods:

  • Synthesized a single-stranded DNA aptamer backbone.
  • Reacted DNA phosphate with molybdate to form redox molybdophosphate precipitate, inducing current.
  • Employed a sandwich detection assay using a HER2-specific peptide and aptamer on a gold electrode.
  • Measured electrochemical current generated by the aptasensor in response to HER2.

Main Results:

  • Successfully demonstrated DNA's ability to generate a redox electric current (∼16.8 μA/μM cm²).
  • Developed an aptasensor for HER2 detection with a linear response from 0.01 to 5 ng/mL.
  • Achieved electrochemical current generation in the range of ∼6.37 to 31.8 μA/cm² in buffer and serum.
  • Confirmed detection levels are clinically relevant for HER2 concentrations.

Conclusions:

  • DNA can be utilized as a transducer to generate electrochemical signals.
  • This novel approach simplifies aptasensor signal transduction for HER2 analysis.
  • The method is universally extendable to other aptasensors for diverse biodetection applications.
  • DNA-generated electric currents have potential applications in molecular electronics and implanted devices.