Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pigmentation01:19

Pigmentation

4.8K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.8K
Skin Cancer01:30

Skin Cancer

6.4K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.4K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

8.5K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.5K
Mutations01:35

Mutations

44.9K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
44.9K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.9K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

5.4K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neisseria Meningitides in Urogenital Infection.

Indian journal of dermatology, venereology and leprology·2017
Same author

Pyoderma Gangrenosum.

Indian journal of dermatology, venereology and leprology·2017
Same author

Needs" in Patients of Neurodermatitis Circumscripta (Lichen Simplex Chronicus).

Indian journal of dermatology, venereology and leprology·2017
Same author

Acrodermatitis Enteropathica.

Indian journal of dermatology, venereology and leprology·2017
Same author

Localised hypertrichosis due to oral 8-MOP.

Indian journal of dermatology, venereology and leprology·2017
Same author

Puvasol Induced Lickenoid Eruption.

Indian journal of dermatology, venereology and leprology·2017
Same journal

Severe combined immunodeficiency (SCID) with pigmentary mosaicism: A coincidental occurrence in a child.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Agminated multifocal eruptive lobular capillary haemangiomas - An uncommon presentation.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Patch testing in India: Are we missing clinically relevant allergens?

Indian journal of dermatology, venereology and leprology·2026
Same journal

Double-loading technique for improved suspension retention on the recipient site in non-cultured epidermal cell suspension (NCES).

Indian journal of dermatology, venereology and leprology·2026
Same journal

Late-onset metastatic melanoma arising from a medium-sized congenital melanocytic naevus.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Custom-compounded glycine-proline jelly for ulcers in prolidase deficiency.

Indian journal of dermatology, venereology and leprology·2026
See all related articles

Related Experiment Video

Updated: Mar 7, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.6K

Psoriasis, Psoralen and Sunlight.

R P C Naik, Gurumohan Singh

    Indian Journal of Dermatology, Venereology and Leprology
    |February 23, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Photoactive furocumarins with ultraviolet light can treat psoriasis. Sunlight exposure with topical or oral 4,5,8-trimethylpsoralen showed some faster lesion clearance compared to controls in limited patient groups.

    More Related Videos

    Minimal Erythema Dose MED Testing
    06:24

    Minimal Erythema Dose MED Testing

    Published on: May 28, 2013

    43.0K
    Studying Chronic Exposure of Mice to Ultraviolet B Radiation
    03:20

    Studying Chronic Exposure of Mice to Ultraviolet B Radiation

    Published on: August 19, 2025

    2.1K

    Related Experiment Videos

    Last Updated: Mar 7, 2026

    The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
    11:39

    The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

    Published on: July 11, 2013

    39.6K
    Minimal Erythema Dose MED Testing
    06:24

    Minimal Erythema Dose MED Testing

    Published on: May 28, 2013

    43.0K
    Studying Chronic Exposure of Mice to Ultraviolet B Radiation
    03:20

    Studying Chronic Exposure of Mice to Ultraviolet B Radiation

    Published on: August 19, 2025

    2.1K

    Area of Science:

    • Dermatology
    • Phototherapy
    • Pharmacology

    Background:

    • Psoriasis is a chronic inflammatory skin condition.
    • Photoactive furocumarins and ultraviolet light therapy (PUVA) are established treatments for psoriasis.
    • Previous studies utilized artificial UV light sources.

    Purpose of the Study:

    • To evaluate the efficacy of sunlight as a UV light source for treating psoriatic lesions.
    • To compare topical versus oral administration of 4,5,8-trimethylpsoralen when combined with sunlight exposure.

    Main Methods:

    • Two paired comparison studies were conducted.
    • Patients received either topical or oral 4,5,8-trimethylpsoralen.
    • Lesion clearance was compared between drug-treated sites and control sites following sunlight exposure.

    Main Results:

    • Two out of 21 patients on topical therapy showed faster lesion clearance on drug-treated sites.
    • None of the 6 patients on oral therapy showed faster clearance on drug-treated sites compared to controls.

    Conclusions:

    • Sunlight may be a viable alternative UV source for topical photochemotherapy in psoriasis.
    • Oral 4,5,8-trimethylpsoralen with sunlight showed limited benefit in this study.
    • Further research is needed to optimize sunlight-based phototherapy for psoriasis.