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Interrelation between plasma kinin and the sympathetic nervous system in normal subjects
H Ishida1, K Shimamoto, T Ando
1Second Department of Internal Medicine, Sapporo Medical College, Japan.
Journal of Clinical Hypertension
|September 1, 1987
Summary
Elevated norepinephrine levels, whether endogenous or exogenous, decrease plasma kinin levels. This suggests a close interrelationship between the sympathetic nervous system and the kinin system.
Area of Science:
- Physiology
- Pharmacology
Background:
- The sympathetic nervous system and kinin system are crucial for regulating physiological functions.
- Understanding their interaction is vital for cardiovascular research.
Purpose of the Study:
- To investigate the relationship between plasma kinin and sympathetic nervous system activity.
- To determine the effect of norepinephrine on plasma kinin levels.
Main Methods:
- Measured plasma kinin, norepinephrine, and angiotensin-I-converting enzyme (ACE) activity in normal subjects.
- Administered subpressor and pressor doses of norepinephrine via infusion.
- Performed 60-degree head-up tilting to stimulate the sympathetic nervous system.
Main Results:
- Norepinephrine infusion significantly decreased plasma kinin levels.
- Head-up tilting also significantly decreased plasma kinin levels.
- Plasma ACE activity remained unchanged during norepinephrine infusion.
Conclusions:
- Increased plasma norepinephrine levels are associated with decreased plasma kinin levels.
- Suggests a significant interrelationship between the sympathetic nervous system and the kinin system.
- Further research is warranted to elucidate the mechanisms of this interaction.