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Relationship Between γ-Glutamyltransferase Levels and Left Ventricular Diastolic Dysfunction.
Seungho Ryu1,2,3, Yoosoo Chang1,2,3, Jeonggyu Kang2
1Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
Summary
Higher serum gamma-glutamyltransferase (GGT) levels are associated with left ventricular (LV) diastolic dysfunction and LV hypertrophy in adults. This finding highlights a potential link between GGT and cardiac abnormalities.
Area of Science:
- Cardiology
- Biochemistry
- Public Health
Background:
- Serum gamma-glutamyltransferase (GGT) is an enzyme linked to various health conditions.
- Left ventricular (LV) diastolic dysfunction and hypertrophy are significant indicators of cardiac health.
Purpose of the Study:
- To investigate the association between serum GGT levels and the presence of LV diastolic dysfunction and LV hypertrophy.
- To explore potential correlations in a large population cohort.
Main Methods:
- A cross-sectional study involving 79,459 Korean adults who underwent echocardiography.
- LV diastolic dysfunction and hypertrophy were diagnosed via echocardiography.
- Statistical analysis included multivariable adjustments and interaction analysis with age.
Main Results:
- Elevated serum GGT levels were significantly associated with both LV diastolic dysfunction and LV hypertrophy.
- Odds ratios for LV diastolic dysfunction increased with higher GGT quartiles (OR 2.23 for highest quartile).
- Odds ratios for LV hypertrophy also showed a trend with higher GGT levels (P for trend = 0.01).
Conclusions:
- A positive association exists between serum GGT levels and LV diastolic dysfunction and hypertrophy.
- This relationship was observed independently of potential confounding factors.
- Age was found to modify the association between GGT and cardiac abnormalities.
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