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Vitamin D supplementation improves simvastatin-mediated decline in exercise performance: A randomized double-blind
Mandeep Singla1, Ashu Rastogi1, Ashutosh N Aggarwal2
1Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Journal of Diabetes
|February 25, 2017
Summary
Vitamin D supplementation can counteract the negative effects of simvastatin on exercise performance and muscle health in adults with type 2 diabetes. This finding highlights vitamin D
Area of Science:
- Exercise Physiology
- Nutritional Biochemistry
- Endocrinology
Background:
- Type 2 diabetes mellitus (T2DM) is associated with impaired cardiorespiratory fitness and skeletal muscle mitochondrial function.
- Statins, like simvastatin, are commonly prescribed for T2DM patients but may affect exercise capacity.
- Vitamin D deficiency is prevalent in T2DM and may influence muscle health and metabolic function.
Purpose of the Study:
- To investigate the impact of vitamin D supplementation on simvastatin-induced changes in cardiorespiratory fitness and skeletal muscle mitochondrial content in T2DM patients.
- To compare the effects of simvastatin alone, simvastatin plus vitamin D, and vitamin D alone on exercise parameters.
Main Methods:
- A 12-week randomized controlled trial involving vitamin D-deficient T2DM patients (aged 25-50 years) undergoing moderate-intensity aerobic exercise.
- Intervention groups received simvastatin (40 mg/day), simvastatin (40 mg/day) plus vitamin D (60,000 IU/week), or vitamin D (60,000 IU/week) alone.
- Primary outcomes measured were peak oxygen consumption (cardiorespiratory fitness) and citrate synthase activity (skeletal muscle mitochondrial content).
Main Results:
- Simvastatin monotherapy led to an 8.4% decrease in cardiorespiratory fitness and a 3.6% reduction in mitochondrial content.
- Vitamin D supplementation blunted the decline in cardiorespiratory fitness (0.6% change) and improved mitochondrial content by 12.1% compared to simvastatin alone.
- Vitamin D alone significantly increased cardiorespiratory fitness (7.1%) and mitochondrial content (16.7%).
Conclusions:
- Simvastatin may negatively impact exercise-associated cardiorespiratory fitness and skeletal muscle mitochondrial content in T2DM patients.
- Vitamin D supplementation appears to mitigate these adverse effects.
- Vitamin D alone demonstrates beneficial effects on exercise capacity and muscle mitochondrial health in this population.
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