Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

David Grabli1

  • 1Université de la Sorbonne, UPMC Paris 06 UMR S 1127, institut du cerveau et de la moelle, Inserm U 1127 et CIC-1422, CNRS UMR 7225, 75013 Paris, France; AP-HP, hôpital Pitié-Salpêtrière, département des maladies du système nerveux, 75013 Paris, France.

Presse Medicale (Paris, France : 1983)
|February 25, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Continuous Apomorphine Infusion in Multiple System Atrophy Real-World Insights From a French Nationwide Retrospective Cohort.

Movement disorders clinical practice·2026
Same author

Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies.

Nature genetics·2026
Same author

No role of intronic expansions in HSF1 for essential tremor in Europe.

Brain : a journal of neurology·2026
Same author

Continuous subcutaneous apomorphine infusion to improve comfort in advanced degenerative Parkinsonian syndrome patients: a retrospective descriptive study in a home-based setting.

Parkinsonism & related disorders·2026
Same author

Understanding dopaminergic dose reduction following STN-DBS: mediation analysis.

BMJ neurology open·2026
Same author

Divergent Cerebello-Cortical Network Responses to Emotional Stress in Myoclonus Dystonia.

Movement disorders : official journal of the Movement Disorder Society·2026
Same journal

Artificial Intelligence in medical research and publishing: progress, risks, and future perspectives.

Presse medicale (Paris, France : 1983)·2026
Same journal

Ethical, legal, and regulatory challenges in AI-based healthcare tools.

Presse medicale (Paris, France : 1983)·2026
Same journal

Decision-making for clinicians.

Presse medicale (Paris, France : 1983)·2026
Same journal

Beyond one-size-fits-all: Personalising health communication to drive real behaviour change.

Presse medicale (Paris, France : 1983)·2026
Same journal

Metacognition and post-decisional processing in clinical decision-making.

Presse medicale (Paris, France : 1983)·2026
Same journal

Fast-and-frugal decision trees for clinicians.

Presse medicale (Paris, France : 1983)·2026
See all related articles

Parkinsonian syndrome arises from nigro-striatal pathway damage, with akinesia as a key symptom. Early gait issues suggest atypical parkinsonism, while late-onset problems are typical of Parkinson's disease.

Area of Science:

  • Neurology
  • Neuroscience
  • Movement Disorders

Background:

  • Parkinsonian syndrome results from damage to the nigro-striatal dopaminergic pathway.
  • Akinesia is the primary clinical manifestation of parkinsonism.
  • Clinical diagnosis can be guided by analyzing motor symptoms.

Purpose of the Study:

  • To differentiate Parkinson's disease from atypical parkinsonian syndromes based on clinical presentation.
  • To highlight the diagnostic significance of symptom onset and progression.

Main Methods:

  • Clinical analysis of motor symptoms in patients with parkinsonian syndromes.
  • Evaluation of symptom progression, including motor complications and gait disturbances.

Main Results:

Related Experiment Videos

  • Parkinson's disease presents as a pure, asymmetric parkinsonian syndrome responsive to dopaminergic treatment.
  • Motor complications like dyskinesia and fluctuations characterize Parkinson's disease evolution.
  • Late-onset gait disturbances (postural instability, freezing) are typical of Parkinson's disease.

Conclusions:

  • Early gait disturbances within three years of onset are indicative of atypical parkinsonian syndromes.
  • The timing of gait issues is a crucial differentiator between Parkinson's disease and atypical parkinsonism.