Related Experiment Video
Updated: Jul 22, 2026

12:42
Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
Published on: December 28, 2014
16.2K
Imported malaria in children in Madrid, Spain, 2007-2013
Beatriz Soto Sánchez1, L M Prieto Tato1, S Guillén Martín1
1Department of Pediatrics, Hospital Universitario de Getafe, Madrid, Spain.
Enfermedades Infecciosas Y Microbiologia Clinica
|February 27, 2017
Summary
Imported malaria in children visiting friends and relatives (VFRs) is a significant concern in Europe. VFRs experienced delayed diagnosis and more severe symptoms, highlighting the need for better travel health education.
Area of Science:
- Pediatric Infectious Diseases
- Travel Medicine
- Epidemiology
Background:
- Imported malaria cases in Europe are predominantly diagnosed in individuals visiting friends and relatives (VFRs).
- Children represent 15-20% of imported malaria cases and face a higher risk of severe disease.
Purpose of the Study:
- To analyze imported malaria cases in children under 16 years old in Madrid, Spain.
- To identify risk factors and clinical characteristics associated with malaria in pediatric VFRs.
Main Methods:
- Retrospective multicenter study conducted in 24 hospitals in Madrid.
- Inclusion criteria: patients under 16 years diagnosed with malaria between 2007 and 2013.
Main Results:
- 149 malaria episodes were reported in 147 children, with Plasmodium falciparum being the most common species.
- Twenty-five patients developed severe malaria, and one death occurred.
- VFRs constituted 45.8% of cases, with inadequate prophylaxis uptake (only 17/149 received it, 4 appropriately).
- VFRs presented with more frequent and prolonged fever, delayed diagnosis (>3 days), and higher rates of thrombocytopenia compared to non-VFRs (p<0.05).
Conclusions:
- VFRs are a significant population for imported pediatric malaria.
- Inadequate prophylaxis and delayed medical consultation in VFRs contribute to prolonged illness and diagnostic delays.
- Enhanced pre-travel education and preventive advice are crucial for VFRs to mitigate malaria risks.
Related Concept Videos
Symbiosis
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
Malaria
Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

