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Updated: Mar 7, 2026

Detecting Amyloid-β Accumulation via Immunofluorescent Staining in a Mouse Model of Alzheimer's Disease
Published on: April 19, 2021
Systemic Amyloidosis Model on Young Mice
V A Kozlov1, S P Sapozhnikov2, P B Karyshev3
1Department of Medical Biology with a Course of Microbiology and Virology, Cheboksary, Russia. pooh12@yandex.ru.
Abstract:
Subcutaneous daily injection (with neglect of aseptics) of 0.5 ml solution of soybean cream substitute (10% volume in distilled water) during 30 days caused systemic amyloidosis in 30-day-old mice. All the known methods for induction of systemic amyloidosis are based on the use of old animals, as senile tissue bradytrophy allows effective simulation of amyloidosis.
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