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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
Published on: September 13, 2024
994
MYC in Regulating Immunity: Metabolism and Beyond.
J N Rashida Gnanaprakasam1, Ruoning Wang2
1Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH 43205, USA. josephin.gnanaprakasam@nationwidechildrens.org.
Genes
|March 2, 2017
Summary
The MYC oncogene family, including c-Myc, regulates cell death, proliferation, and metabolism. MYC family members are crucial for immune cell development, differentiation, and activation, impacting immune responses and metabolism.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- MYC oncogene family members (c-Myc, MYCN, MYCL) are key drivers in human cancers.
- MYC proteins regulate cell death, proliferation, and metabolism.
- MYC family expression is tightly controlled in immune cells.
Purpose of the Study:
- To discuss the role of MYC family members in the immune system.
- To explore how MYC impacts immune metabolism and responses.
Main Methods:
- Review of existing literature on MYC biology and immune function.
- Analysis of MYC's role as a transcription factor in immune cells.
Main Results:
- MYC family members are essential for immune cell development, differentiation, and activation.
- MYC proteins coordinate metabolic programs in immune cells to support immune functions.
- MYC dysregulation impacts immune metabolism and responses.
Conclusions:
- MYC family members play critical roles in immune system regulation.
- Understanding MYC's function in immune metabolism offers therapeutic potential for immunological diseases.
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