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[Effect of hypercapnic hypoxia on chronic abacterial prostatitis].

A I Neimark1, S S Maksimova1

  • 1Department of Urology and Nephrology of Altai State Medical University of Minzdrav of Russia, Barnaul.

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|March 2, 2017
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Summary

Hypercapnic hypoxia combined with basic therapy significantly improved chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) symptoms. This integrated approach enhanced prostate microcirculation and reduced pain and urinary issues more effectively than basic therapy alone.

Keywords:
chronic abacterial prostatitishypercapniahypoxiamicrocirculation of the prostate

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Area of Science:

  • Urology
  • Respiratory Medicine
  • Physiology

Background:

  • Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) presents challenges in treatment, with standard therapies offering limited improvements in microcirculation.
  • Understanding the impact of novel therapeutic approaches on prostate hemodynamics and tissue oxygenation is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To evaluate the efficacy of hypercapnic hypoxia as an adjunct to standard therapy for patients diagnosed with CP/CPPS.
  • To assess the impact of this integrated treatment on prostate microcirculation, hemodynamics, and clinical manifestations.

Main Methods:

  • A randomized controlled trial involving 37 male patients with CP/CPPS.
  • The study group received basic therapy plus 10 sessions of hypercapnic hypoxia, while the control group received basic therapy alone.
  • Outcome measures included clinical symptom assessment, digital rectal examination (DRE), transrectal ultrasound (TRUS), uroflowmetry, and laser Doppler flowmetry.

Main Results:

  • Both groups experienced symptom relief, but the hypercapnic hypoxia group showed significantly greater improvement in pain and dysuria.
  • While DRE and TRUS findings were similar, laser Doppler flowmetry indicated improved prostate microcirculation in the study group.
  • The study group demonstrated enhanced blood flow, perfusion, and reduced tissue hypoxia compared to the control group.

Conclusions:

  • Basic therapy for CP/CPPS provides limited benefits for prostate hemodynamics and microcirculation.
  • Hypercapnic hypoxia as part of combination therapy significantly enhances treatment effectiveness by improving microcirculation and reducing clinical symptoms.
  • The use of the "Karbonik" breathing simulator is recommended for combination therapy in CP/CPPS patients to increase treatment efficacy.