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Updated: Mar 7, 2026

Analysis of SNARE-mediated Membrane Fusion Using an Enzymatic Cell Fusion Assay
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Artificial Membrane Fusion Triggered by Strain-Promoted Alkyne-Azide Cycloaddition

Stuart A Whitehead1, Christopher D McNitt2, Samuel I Mattern-Schain1

  • 1Department of Chemistry, University of Tennessee , Knoxville, Tennessee 37996, United States.

Bioconjugate Chemistry
|March 2, 2017
PubMed
Summary

Researchers developed novel lipids for controlled membrane fusion using strain-promoted alkyne-azide cycloaddition (SPAAC). Oxo-dibenzocyclooctyne (ODIBO)-lipid 1 demonstrated superior fusion triggering for potential drug delivery applications.

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