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Design and Feasibility Study of a Single Photon Emission Microscope System for Small Animal I-125 Imaging
L J Meng1, N H Clinthorne2, S Skinner3
1Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 USA.
Abstract:
This paper presents a design study of a single photon emission microscope (SPEM) system for small animal imaging using I-125 labelled radiotracers. This system is based on the use of a very-high resolution gamma camera coupled to a converging non-multiplexing multiple pinhole collimator. This enables one to "zoom" into a small local region inside the object to extract imaging information with a very high spatial resolution and a reasonable sensitivity for gamma rays emitted from this local region. The SPEM system also includes a pinhole (or multiple pinhole) gamma camera that has a full angular coverage of the entire object. The designed imaging spatial resolution for the SPEM system is between 250 μm to 500 μm FWHM.
