Related Experiment Video
Updated: Mar 6, 2026
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Personalized medicine and chronic obstructive pulmonary disease
E F M Wouters1, B B R A F Wouters, I M L Augustin
1aDepartment of Respiratory Diseases, Maastricht University Medical Center, Maastricht bCentre of Expertise for Chronic Organ Failure, Horn, The Netherlands cDepartment of Health, Ethics and Society, Faculty of Health Medicine and Life Science, CAPHRI School for Public Health and Primary Care.
Personalized medicine in chronic obstructive pulmonary disease (COPD) requires a holistic patient approach beyond spirometry. Future advancements depend on identifying specific COPD endotypes and phenotypes for tailored treatments.
Area of Science:
- Pulmonary Medicine
- Genetics
- Systems Biology
Background:
- Current chronic obstructive pulmonary disease (COPD) management relies on spirometry, a reductionist approach.
- Existing recommendations for COPD lack personalized management algorithms.
- COPD is a complex, heterogeneous disease with multifactorial origins.
Purpose of the Study:
- To review developments in personalized and precision medicine for COPD.
- To explore a holistic, systems-based approach to personalized COPD care.
- To highlight targeted interventions and genetic endotype-based therapies.
Main Methods:
- Literature review of personalized and precision medicine in COPD.
- Analysis of current COPD management strategies.
- Examination of inflammatory processes and genetic endotypes in COPD.
Main Results:
- Personalized medicine in COPD necessitates a holistic patient view, considering complex system interactions.
- Pulmonary rehabilitation serves as a model for personalized COPD care.
- Augmentation therapy for alpha-1-antitrypsin deficiency exemplifies precision medicine based on genetic endotypes.
Conclusions:
- Future precision medicine in COPD hinges on identifying relevant endotypes.
- Accurate identification of phenotypes is crucial for managing COPD's complex manifestations.
- Integrating endotype and phenotype data will advance personalized COPD treatment strategies.
Related Concept Videos
01:29Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
01:24Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
01:20COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:26COPD: Management Using Bronchodilators and Corticosteroids