Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cushing's disease.

D C Aron1, J W Findling, J B Tyrrell

  • 1Case Western Reserve University, Cleveland, Ohio.

Endocrinology and Metabolism Clinics of North America
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of interviewing in endocrine practice.

Journal of endocrinological investigation·2025
Same author

Lower extremity insufficiency fractures: an underappreciated manifestation of endogenous Cushing's syndrome.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2016
Same author

High variability in baseline urinary free cortisol values in patients with Cushing's disease.

Clinical endocrinology·2013
Same author

The use of mifepristone in the treatment of Cushing's syndrome.

Drugs of today (Barcelona, Spain : 1998)·2012
Same author

A case study of translating ACGME practice-based learning and improvement requirements into reality: systems quality improvement projects as the key component to a comprehensive curriculum.

Postgraduate medical journal·2009
Same author

A case study of translating ACGME practice-based learning and improvement requirements into reality: systems quality improvement projects as the key component to a comprehensive curriculum.

Quality & safety in health care·2009
Same journal

Navigating Adrenal Disease: A Comprehensive, Practical Guide for the Clinician.

Endocrinology and metabolism clinics of North America·2026
Same journal

Adrenal Disorders in Pregnancy.

Endocrinology and metabolism clinics of North America·2026
Same journal

Diagnosis and Management of Adrenocortical Carcinoma.

Endocrinology and metabolism clinics of North America·2026
Same journal

Pheochromocytomas and Paragangliomas.

Endocrinology and metabolism clinics of North America·2026
Same journal

Hereditary Conditions Associated with Adrenocortical Carcinoma, Pheochromocytoma, and Other Adrenal Tumors: Genetic Testing and Management Recommendations.

Endocrinology and metabolism clinics of North America·2026
Same journal

Primary Bilateral Macronodular Adrenal Hyperplasia.

Endocrinology and metabolism clinics of North America·2026
See all related articles

Cushing's disease, caused by excess pituitary ACTH, affects women and requires documenting hypercortisolism for diagnosis. Transsphenoidal surgery is the primary treatment for these pituitary adenomas.

Area of Science:

  • Endocrinology
  • Oncology
  • Neurosurgery

Background:

  • Cushing's disease is a subtype of Cushing's syndrome characterized by persistent, inappropriate hypercortisolism.
  • It stems from the pituitary gland overproducing ACTH, accounting for 70% of adult Cushing's syndrome cases.
  • The condition predominantly affects women of childbearing age.

Purpose of the Study:

  • To discuss the pathology, etiology, and clinical and laboratory features of Cushing's disease.
  • To outline the diagnostic process for Cushing's disease.
  • To review treatment options for Cushing's disease.

Main Methods:

  • Review of pathology, causes, and clinical/laboratory features.
  • Diagnostic criteria for endogenous hypercortisolism.

Related Experiment Videos

  • Surgical, radiotherapeutic, and medical treatment modalities.

    • Main Results:

    • Diagnosis involves documenting hypercortisolism and identifying the cause.
    • Selective transsphenoidal resection of pituitary adenomas is the preferred initial treatment.
    • Radiotherapy and medical therapies serve as alternative or adjunctive treatments.

    Conclusions:

    • Cushing's disease requires a systematic diagnostic approach.
    • Transsphenoidal surgery offers the best initial therapeutic outcome.
    • Multimodal treatment strategies may be necessary for comprehensive management.