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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
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Pathways for Neuroimaging of Neonatal Stroke
Sarah Lee1, David M Mirsky2, Lauren A Beslow3
1Department of Neurology & Neurological Sciences, Stanford Hospital and Clinics, Stanford School of Medicine, Stanford, California.
Pediatric Neurology
|March 7, 2017
Summary
Magnetic resonance imaging (MRI) is recommended for diagnosing neonatal stroke, offering superior detail without radiation. Consensus protocols guide imaging for stroke subtypes, aiding timely and accurate diagnosis in infants.
Area of Science:
- Neurology
- Radiology
- Pediatrics
Background:
- Neonatal stroke diagnosis requires standardized imaging protocols.
- International experts convened to establish consensus guidelines.
- Focus on arterial ischemic stroke, cerebral sinovenous thrombosis, and hemorrhagic stroke.
Framework:
- Consensus-based imaging protocols for neonatal stroke.
- Utilizes National Institute of Neurological Disorders and Stroke Common Data Elements for stroke classification.
- Reviews epidemiology, clinical presentation, and risk factors.
Implementation:
- Magnetic resonance imaging (MRI) is the preferred modality.
- Recommended MRI sequences: diffusion-weighted imaging, apparent diffusion coefficient mapping, gradient-recalled echo/susceptibility-weighted imaging, T1- and T2-weighted imaging.
- Magnetic resonance angiography and venography for vascular assessment.
Implications:
- Facilitates accurate and timely diagnosis of neonatal stroke.
- Provides guidance for practitioners in diagnosing stroke subtypes.
- Highlights the role of advanced neuroimaging techniques.

