The association between subjective memory complaint and objective cognitive function in older people with previous...

Area of Science:

• Neuroscience
• Gerontology
• Psychiatry

Background:

• Older adults with a history of major depression are at increased risk for cognitive impairment and dementia.
• Subjective memory complaints (SMC) are common in this population but their association with objective cognitive performance requires further investigation.

Purpose of the Study:

• To examine the relationship between subjective memory complaints and objective cognitive function in older adults with a history of major depression.

Main Methods:

• A cross-sectional study comparing 113 older adults with previous major depression to 46 healthy controls.
• Cognitive function assessed via tests of verbal memory, attention, visuospatial skills, verbal fluency, and cognitive flexibility.
• Subjective memory complaint defined by a score >=4 on the Geriatric Mental State schedule.

Main Results:

• Over half of participants with a history of depression reported subjective memory complaints (55.8%).
• SMC was associated with lower immediate and delayed verbal recall scores in the depression history group.
• This association was stronger in individuals with fewer current depressive symptoms (Hamilton Depression Rating Scale score < 7).

Conclusions:

• Subjective memory complaints appear to be a valid indicator of objective memory performance in older adults with prior major depression.
• Proactive assessment and follow-up of memory complaints are recommended for this clinical population.