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    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |March 9, 2017
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    Summary

    Researchers are developing wearable hemodialysis (HD) devices for end-stage-renal disease (ERD) patients. Their novel nanoporous membranes achieve high toxin clearance, showing promise for a portable dialysis unit prototype.

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    Area of Science:

    • Biomedical Engineering
    • Materials Science
    • Nephrology

    Background:

    • Center-based hemodialysis (HD) is a standard treatment for end-stage-renal disease (ERD).
    • Current HD treatments significantly impact patients' quality of life.
    • Wearable dialysis devices offer a potential alternative to improve patient outcomes and quality of life.

    Purpose of the Study:

    • To develop highly efficient membranes for wearable dialysis devices.
    • To create a prototype wearable dialysis unit.
    • To assess the performance and robustness of the novel membrane technology.

    Main Methods:

    • Fabrication of ultrathin nanoporous membranes with high permeability.
    • Benchtop studies using a small animal model to evaluate urea clearance.
    • Mechanical testing and optimization of high membrane area dialysis devices.

    Main Results:

    • The novel nanoporous membrane material demonstrates significantly higher permeability than conventional HD membranes.
    • Clinical levels of urea clearance were achieved in a small animal model at low blood flow rates.
    • Progress has been made in improving the mechanical robustness of the dialysis devices.

    Conclusions:

    • The developed ultrathin nanoporous membranes are highly efficient for toxin clearance.
    • The prototype wearable dialysis unit shows promise for effective hemodialysis in a portable format.
    • Further development in mechanical robustness is ongoing to ensure device viability.