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Related Concept Videos

Protein Folding01:25

Protein Folding

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Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
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The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Related Experiment Video

Updated: Mar 6, 2026

Fabrication of Three-Dimensional Graphene-Based Polyhedrons via Origami-Like Self-Folding
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Sequential self-folding of polymer sheets.

Ying Liu1, Brandi Shaw1, Michael D Dickey1

  • 1Department of Chemical and Biomolecular Engineering, North Carolina State University, 911 Partners Way, Raleigh, NC 27695, USA.

Science Advances
|March 10, 2017
PubMed
Summary
This summary is machine-generated.

Researchers demonstrate a simple method for programming polymer sheets to self-fold into 3D objects using light. This light-activated shape transformation allows for sequential folding, enabling complex structures from 2D materials.

Keywords:
shape memory origami polymer self-folding

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Area of Science:

  • Materials Science
  • Polymer Science
  • Soft Robotics

Background:

  • Material shape is critical for function, especially in natural systems.
  • Existing shape-changing material strategies lack precise temporal and spatial control.
  • Sequential shape transformation is desired for complex structure generation and material versatility.

Purpose of the Study:

  • To present a simple strategy for programmed self-folding of 2D polymer sheets into 3D objects.
  • To demonstrate temporal and spatial control over shape transformation using external light.
  • To enable the creation of multiple shapes from a single starting material.

Main Methods:

  • Utilizing 2D polymer sheets with printed ink patterns.
  • Employing external light with specific wavelengths to activate ink.
  • Ink absorption of light generates heat, inducing strain relief and controlled folding at designated hinges.

Main Results:

  • Achieved programmed, sequential self-folding of polymer sheets into 3D structures.
  • Demonstrated precise spatial control of folding using color patterns and light wavelengths.
  • Showcased temporal control by selectively activating different colored inks with specific light.

Conclusions:

  • Developed a straightforward method for light-induced, programmed material self-folding.
  • The technique offers precise temporal and spatial control over shape transformation.
  • Potential applications include reconfigurable electronics, actuators, sensors, and deployable structures.