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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents
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Bioresorbable Polymers and Stent Devices.

Payam Dehghani1

  • 1Prairie Vascular Research Network, Regina General Hospital Unit 3A(CCU), Regina Qu'Appelle Health Region, University of Saskatchewan, Interventional Cardiology Research Office, 1440-14th Ave, Regina, SK, S4P 0W5, Canada. pdehghani@mac.com.

Current Treatment Options in Cardiovascular Medicine
|March 10, 2017
PubMed
Summary
This summary is machine-generated.

New drug-eluting platforms (DES) with bioabsorbable polymers offer potential advantages over durable polymer DES. However, more long-term clinical data from randomized controlled trials are needed before widespread adoption in interventional cardiology.

Keywords:
AngioplastyBare metal stentBioabsorbable polymerBioresorbable scaffoldDrug-eluting stentStent thrombosis

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Area of Science:

  • Interventional Cardiology
  • Cardiovascular Devices
  • Biomaterials Science

Background:

  • Current drug-eluting platforms (DES) have significantly improved safety and efficacy.
  • Patient preference and biological plausibility support the development of bioabsorbable polymer DES (BP DES) and bioresorbable scaffolds (BRS).
  • BP DES aim to restore normal coronary physiology and vascular function, offering potential advantages over durable polymer DES.

Purpose of the Study:

  • To evaluate the current status and future potential of bioabsorbable polymer DES and bioresorbable scaffolds in percutaneous coronary interventions.
  • To discuss the readiness of these novel devices for widespread clinical use.
  • To highlight the need for robust clinical evidence to support their long-term efficacy and safety.

Main Methods:

  • Review of existing literature and preclinical data on bioabsorbable polymer DES and bioresorbable scaffolds.
  • Discussion of mechanistic data, including endothelialization, optical coherence tomography (OCT) imaging, and vasomotion.
  • Emphasis on the necessity of randomized controlled trials (RCTs) for definitive outcome assessment.

Main Results:

  • BP DES have demonstrated non-inferiority in selected patient populations, but long-term data are limited.
  • Preclinical and mechanistic data suggest potential benefits in restoring vascular function and adaptive responses.
  • Current evidence is insufficient to recommend widespread adoption over best-in-class durable polymer DES.

Conclusions:

  • While promising, bioabsorbable polymer DES and bioresorbable scaffolds are not yet ready for prime time in routine clinical practice.
  • Rigorous, long-term randomized controlled trials are essential to compare their outcomes against durable polymer DES.
  • Further research and disciplined implantation techniques are required, with definitive evidence likely a decade away.