Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.6K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.6K
Inflammation01:38

Inflammation

63.2K
Overview
63.2K
T Cell Types and Functions01:24

T Cell Types and Functions

3.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.0K
Inflammatory Response01:28

Inflammatory Response

17.7K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
17.7K
Autoimmune Disorders01:29

Autoimmune Disorders

2.0K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.0K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

789
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
789

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Muscle Tissue Remodeling Following Intramuscular Fat Grafting: Structural and Transcriptomic Insights.

Aesthetic surgery journal·2026
Same author

Impact of Menopausal Status on Bone Metabolism and Body Composition After Metabolic-Bariatric Surgery: a Two-Year Prospective Study in Middle-Aged Women.

Obesity surgery·2026
Same author

Microvascular, Biochemical, and Clinical Impact of Hyperbaric Oxygen Therapy in Recalcitrant Diabetic Foot Ulcers.

Cells·2025
Same author

Acute intravascular haemolysis rapidly shifts the balance of angiogenic factors and accelerates neovascularization in vivo.

British journal of haematology·2025
Same author

Gut Microbiota Is Not Significantly Altered by Radioiodine Therapy.

Nutrients·2025
Same author

Cytomegalovirus Infection in an Immunocompetent Host Presenting as Hemophagocytic Lymphohistiocytosis.

European journal of case reports in internal medicine·2025

Related Experiment Video

Updated: Mar 6, 2026

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
05:26

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

2.1K

Inflammation in Sjögren's syndrome: Cause or consequence?

Ana Raquel Rodrigues1, Raquel Soares1,2

  • 1a Department of Biochemistry , Faculty of Medicine, University of Porto , Porto , Portugal and.

Autoimmunity
|March 10, 2017
PubMed
Summary

Sjögren's syndrome involves inflammation and immune system dysregulation, leading to glandular damage and increased lymphoma risk. Current treatments remain insufficient for this complex autoimmune condition.

Keywords:
Clinicopathological parametersanti-inflammatory therapeuticscytokinesinflammatory cellsplasmacytoid dendritic cells

More Related Videos

Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
07:25

Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research

Published on: October 13, 2023

6.0K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

940

Related Experiment Videos

Last Updated: Mar 6, 2026

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
05:26

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

2.1K
Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
07:25

Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research

Published on: October 13, 2023

6.0K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

940

Area of Science:

  • Immunology
  • Rheumatology
  • Pathology

Background:

  • Sjögren's syndrome (SS) is a prevalent autoimmune disorder primarily causing dry eyes and mouth.
  • The exact mechanisms driving SS pathogenesis remain incompletely understood.
  • Chronic inflammation, involving Th1, Th2, and Th17 cytokines, is central to SS pathology.

Purpose of the Study:

  • To elucidate the underlying mechanisms of Sjögren's syndrome.
  • To highlight the role of inflammation and immune dysregulation in SS.
  • To discuss the implications for related rheumatic conditions.

Main Methods:

  • Review of existing literature on Sjögren's syndrome.
  • Analysis of inflammatory pathways and cytokine involvement.
  • Examination of the link between SS and lymphoproliferative diseases.

Main Results:

  • Inflammation, particularly cytokine release, drives glandular atrophy and architectural damage in SS.
  • Germinal center formation in SS significantly elevates the risk of lymphoproliferative diseases.
  • SS is associated with various other autoimmune and auto-inflammatory conditions.

Conclusions:

  • Understanding SS inflammation is crucial for managing the disease and associated conditions.
  • Further research is needed to improve therapeutic strategies for Sjögren's syndrome.
  • This overview provides insights beneficial for SS and other rheumatic diseases.