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Emerging treatments for primary sclerosing cholangitis
Eduardo A Rodriguez1, Elizabeth J Carey1, Keith D Lindor1,2
1a Division of Gastroenterology and Hepatology , Mayo Clinic , Phoenix , AZ , USA.
Expert Review of Gastroenterology & Hepatology
|March 10, 2017
Summary
Primary sclerosing cholangitis (PSC) is a rare liver disease with no effective medical treatments. This review examines past, present, and future therapeutic strategies for PSC, aiming to improve patient outcomes.
Area of Science:
- Hepatology
- Gastroenterology
- Immunology
Background:
- Primary sclerosing cholangitis (PSC) is a chronic, idiopathic liver disease.
- It is associated with inflammatory bowel disease and has a complex pathophysiology.
- PSC can progress to cirrhosis, cholangiocarcinoma, and end-stage liver disease.
Purpose of the Study:
- To review previously tested treatments for PSC.
- To discuss current treatment strategies for PSC.
- To present viewpoints on emerging therapies for PSC.
Main Methods:
- Literature search of PubMed using relevant keywords.
- Inclusion of full-text articles published in English.
- Identification of additional articles from reference lists of reviews.
Main Results:
- No medical therapies have proven effective for PSC to date.
- Liver transplant is the only treatment for end-stage PSC, but recurrence is a complication.
- Therapeutic development for PSC has been challenging.
Conclusions:
- Greater awareness of PSC is increasing.
- New insights into PSC pathophysiology may aid in designing future effective therapies.
- The development of effective treatments for PSC remains a critical unmet need.
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