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Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants
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Peptide-Based and Polypeptide-Based Gene Delivery Systems.

Jie Chen1,2, Xiuwen Guan1,2, Yingying Hu1,2

  • 1Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

Topics in Current Chemistry (Cham)
|March 11, 2017
PubMed
Summary
This summary is machine-generated.

Peptide and polypeptide gene carriers show promise for gene therapy. This review covers their preparation, types, applications, and future development for targeted gene delivery.

Keywords:
Gene deliveryGene vaccineGenetic disordersMultifunctionalPolymeric carriersPolypeptide

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Gene Therapy

Background:

  • Peptide-based and polypeptide-based materials are gaining traction as effective gene carriers.
  • Gene therapy holds significant potential for treating genetic disorders.

Purpose of the Study:

  • To review the preparation methods for peptide and polypeptide gene carriers.
  • To outline the different types of peptide-based gene delivery systems.
  • To discuss their applications and future prospects in gene therapy.

Main Methods:

  • Literature review of peptide and polypeptide synthesis.
  • Analysis of existing gene delivery systems.
  • Examination of published gene therapy applications.

Main Results:

  • Peptides and polypeptides offer versatile platforms for gene delivery.
  • Various strategies exist for preparing these carriers.
  • Diverse applications in gene therapy have been demonstrated.

Conclusions:

  • Peptide and polypeptide gene carriers are promising for advanced gene therapy.
  • Further research can optimize these carriers for specific therapeutic targets.