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Updated: Mar 6, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.6K
[Topical therapy of the scalp]
1Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle (Saale), Deutschland. johannes.wohlrab@medizin.uni-halle.de.
Summary
Topical treatments for hair and skin diseases require specialized formulations. Choosing the right base considers active ingredients, application site, and patient adherence for effective drug delivery.
Area of Science:
- Dermatology
- Pharmaceutics
- Drug Delivery
Background:
- Topical active substances treat various hair diseases, systemic dermatoses, and parasitic infections.
- Hair follicle density and diffusion conditions necessitate tailored galenic formulations for effective treatment.
Purpose of the Study:
- To highlight the importance of specific galenic concepts in topical drug delivery for hair and scalp conditions.
- To discuss factors influencing the choice of galenic bases for optimal therapeutic outcomes.
Main Methods:
- Review of physicochemical properties of active ingredients.
- Analysis of application site characteristics (hairiness, scarring, hyperkeratosis, exoserosis).
- Evaluation of formulation types (low-viscosity bases, foams) and delivery devices.
Main Results:
- Galenic formulation selection must balance active ingredient properties with application site conditions.
- Low-viscosity bases and foams offer good spreadability, enhancing topical treatment efficacy.
- User-friendly packaging (nozzle tips, comb dispensers) improves patient adherence.
Conclusions:
- Optimized galenic formulations and delivery systems are crucial for effective topical treatment of scalp and hair conditions.
- Consideration of patient factors and application site characteristics improves therapeutic success.
- Advanced formulation and packaging strategies can enhance patient compliance and treatment outcomes.
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