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Updated: Mar 6, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Identifying memory impairment and early dementia in primary care
Ellen Grober1, Dorothy Wakefield2, Amy R Ehrlich3
1Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
This study shows that a two-stage screening process effectively identifies older adults with memory impairment or dementia. The method offers high accuracy, aiding early detection in primary care settings.
Area of Science:
- Gerontology
- Neurology
- Public Health
Background:
- Memory impairment and dementia are significant health concerns in aging populations.
- Early identification is crucial for timely intervention and management.
- Existing screening methods may have limitations in primary care settings.
Purpose of the Study:
- To evaluate the operating characteristics of a two-stage case-finding strategy.
- To assess the effectiveness of this strategy in identifying memory impairment and very mild dementia.
- To determine the sensitivity and specificity of the screening process.
Main Methods:
- A two-stage testing approach was implemented in primary care patients.
- Stage one involved screening for subjective cognitive decline using the Informant Questionnaire on Cognitive Decline in the Elderly.
- Stage two involved memory testing with the Free and Cued Selective Reminding Test with Immediate Recall for positive screens.
Main Results:
- The study identified 117 patients (21%) with dementia and 68 (12%) with memory impairment but not dementia.
- The two-stage screening achieved a combined sensitivity of 72% and specificity of 90% in the pooled sample.
- Classification accuracy was not significantly affected by ethnicity, education, or age.
Conclusions:
- Two-stage screening is an efficient method for identifying older adults with memory impairment or dementia.
- This approach can facilitate early detection and intervention in primary care.
- The screening method demonstrates robust performance across diverse demographic groups.
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