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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

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AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
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Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

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Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
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[Type 2 diabetes mellitus in rheumatoid arthritis and systemic lupus erythematosus: A review].

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Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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[Cardiovascular Complications of Rheumatoid Arthritis: Prevalence and Pathogenesis].

L B Krougly1,2, O A Fomicheva1,2, Yu A Karpov1,2

  • 1Myasnikov Clinical Cardiology Institute, Russian Cardiology Research Center, Moscow, Russia.

Kardiologiia
|March 15, 2017
PubMed
Summary
This summary is machine-generated.

Rheumatoid arthritis (RA) patients face high cardiovascular risks beyond typical factors. Systemic inflammation and endothelial dysfunction contribute significantly to these adverse outcomes.

Keywords:
atherosclerosiscardiologycardiovascular complicationsmyocardial infarctionrheumatoid arthritisrheumatologystroke

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Area of Science:

  • Rheumatology
  • Cardiology
  • Immunology

Background:

  • Rheumatoid arthritis (RA) is a chronic inflammatory condition.
  • RA patients exhibit a significantly elevated risk of cardiovascular events, including myocardial infarction and cerebrovascular accidents.
  • Traditional cardiovascular risk factors do not fully account for the heightened risk observed in RA.

Purpose of the Study:

  • To review and present the various risk factors for cardiovascular events in patients with Rheumatoid arthritis.
  • To explore the relationship between RA pathogenesis and the development of cardiovascular disease.
  • To highlight mechanisms beyond classical risk factors contributing to cardiovascular mortality in RA.

Main Methods:

  • Literature review of studies on Rheumatoid arthritis and cardiovascular events.
  • Analysis of risk factors associated with cardiovascular disease in RA patients.
  • Examination of the role of systemic inflammation, arterial stiffness, and endothelial dysfunction.

Main Results:

  • Cardiovascular events are a leading cause of mortality in RA patients.
  • Early and rapid progression of atherosclerotic vascular lesions is observed in RA.
  • Systemic inflammation, increased arterial stiffness, and endothelial dysfunction are implicated as additional mechanisms driving cardiovascular risk.

Conclusions:

  • The high cardiovascular risk in RA is multifactorial, involving both classical and RA-specific factors.
  • Understanding these mechanisms is crucial for managing cardiovascular outcomes in RA patients.
  • Targeting inflammatory pathways and vascular dysfunction may mitigate cardiovascular events in RA.