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Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

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Eccentric Training for Tendon Healing After Acute Lesion: A Rat Model.

Jean-François Kaux¹, Vincent Libertiaux², Pierre Leprince³

¹Physical Medicine, Rehabilitation and Sports Traumatology Department, SportS2, FIFA Medical Centre of Excellence, University and University Hospital of Liège, Liège, Belgium.

The American Journal of Sports Medicine

|March 15, 2017

Summary

Eccentric training significantly improved injured tendon strength in rats, regardless of whether they received platelet-rich plasma (PRP) or physiological fluid injections. This highlights the critical role of rehabilitation in tendon healing.

Keywords:

PRP biomechanics eccentric platelet-rich plasma proteomics tendon

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Area of Science:

Biomechanical Engineering
Regenerative Medicine
Sports Science

Background:

Tendons are dynamic tissues capable of permanent remodeling.
Platelet-rich plasma (PRP) injections show promise for enhancing tendon healing in rat models.
Eccentric exercise is recognized for its potential to improve tendon mechanical properties.

Purpose of the Study:

To investigate the combined efficacy of PRP injection and eccentric training on tendon healing.
To determine if this combination is superior to either treatment alone.

Main Methods:

A controlled laboratory study involving adult male rats with surgically induced patellar tendon lesions.
Randomized injection of physiological fluid (PF) or homologous PRP.
Division into groups with and without eccentric training (3 times/week) for 5 weeks.
Assessment of ultimate tensile strength, energy, and proteomic profiles.

Main Results:

No significant difference in tendon strength was observed between PF and PRP injections alone.
Eccentric training significantly increased ultimate tensile force at rupture by 4.5 N (108% of control, P = .006).
Proteomic analysis indicated that eccentric training modulated cytoskeletal proteins and glycolytic pathway enzymes, suggesting altered metabolic plasticity.

Conclusions:

Eccentric training enhances injured tendon resistance irrespective of concurrent PRP or PF injection.
The findings underscore the essential role of eccentric rehabilitation and training in managing tendon lesions.